ea0081oc12.3 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022
Ludovica Cotellessa
, Federica Marelli
, Duminuco Paolo
, Lucia Bartoloni
, Michela Adamo
, Pitteloud Nelly
, Persani Luca
, Bonomi Marco
, Giacobini Paolo
, Valeria Vezzoli
The precise development of the Gonadotropin Releasing Hormone (GnRH) neurons is essential for the proper function of the hypothalamic-pituitary-gonadal axis, as GnRH is the master regulator of reproductive functions in vertebrates. Mutations in genes involved in the development of GnRH neurons are associated with Congenital Hypogonadotropic Hypogonadism (CHH), a heterogeneous genetic disorder characterized by hypogonadism, lack of puberty onset, and infertility, which is named...